James will follow in the footsteps of David Bowie, Yoko Ono and Jarvis Cocker in curating the event, which will mark its 21st anniversary next year.
His Mo’Wax label will also be 21 years old in 2014, with Mo’Wax21: Urban Archaeology, to feature as part of the festival. This exhibition will celebrate the creative output of the label James launched as a teenager.
James said: ‘I intend to create a vibrant and exciting collage of counter-culture and collaboration from the worlds of music, film, art and everything in between.
‘I want to bring together my influences from the past, the present and my work as an artist in contemporary society as well as transforming the space in a way that’s never been done before, both artistically and musically.’
Jude Kelly, artistic director at Southbank Centre, added: ‘As an artist, James Lavelle has built a phenomenal reputation for innovation, experimentation and collaboration. The defining voice of club culture, his Meltdown will be an amazing celebration of everything he has done and still dreams of doing.’
Meltdown 2014 runs 13 – 22 June with the line up expected to be confirmed closer to the event.